They are releasing a joint album, titled “18,” on July 15.
Their first single, “This Is A Song For Miss Hedy Lamarr,” has been released.
“It’s an extraordinary honor to play and write music with Jeff, one of the true greats and someone I am now privileged enough to call my brother,” Depp added in a statement.
The two have been friends for years and Beck appeared on a song with the Hollywood Vampires, a supergroup Depp formed with musicians Alice Cooper and Joe Perry in 2012.
The actor made headlines when he performed with Beck in England while his defamation trial against his ex-wife Amber Herd was coming to an end.